Changing Perspectives on Nitrate, Nitrite and Nitric Oxide
Eben van Tonder
11 December 2022

Introduction

I’ve spent a lot of time on the historical perspectives that emerged over the last few hundred years about nitrates, nitrites and recently, nitric oxide. I took particular note of the changing attitude towards these over the last 15 years not just from a scientific perspective, but also from a public or consumer perspective. I predicted that the avalanche of scientific data that has been emerging especially since the 1980s would eventually swing public opinion as a more complete role of these species become clear in our everyday lives and as essential to our health. More than this, the health and fitness industry would become the main vector driving change away from the stereotypical negative perspectives as the overwhelming beneficial nature of these species becomes clear to sportsmen and women in particular.

Young people are willing and able to process complex sets of information much more effectively than the older generations which means that they can assimilate more complex information which has traditionally been the main obstacle in communicating a balanced perspective related to nitrite in particular. Nitrite, nitrate, and nitrosamine formation is a complex matter. People my age and older grew up with a more linear perspective on things. Something is black or white, for example, where young people are accustomed to thinking in terms of multi-dimensional worlds with complex sets of data.

This week I came across just such a progression where a brand, in this case, CircO₂ took some complex sets of data, using innovative marketing techniques and positioned a product, associated with nitric oxide and nitrate, not at the young people, but at the aspirational group of middle-aged and senior citizens. When I use the word “aspirational”, I mean this in the sense that they reach back into what influences the young generation and appropriate their new way of thinking for themselves.

I am not promoting CircO₂ as a product. The fact that they use marketing techniques to explain to the general public the essential and beneficial role of nitrate and nitric oxide, and by implication, nitrite also, must be commended. More than this, I propose that the meat industry must do more to aim their own marketing along these lines. There is much we can learn from CircO₂ in terms of their approach. They do not shy away from complex data sets. They embraced it and worked hard to present it in a palatable way to consumers.

Of course, CircO₂ may not appreciate the link with cured meats as it may distract from their central brand message. I do not propose that there is a link except for the fact that the basics that they present as inherently beneficial in their product are exactly what has been presented as the main problem with cured meats for years. Their clear proclamation of the benefits of these reactive nitrogen species will, over time, become the basis of a complete change of attitude by the consumers towards cured meats.

It is imperative that the curing industry embrace the totality of these new findings, not just in its own messaging, but also in its formulations. What I mean is that more fruit and veg hybrids with meat products must be encouraged because the overwhelming evidence is that these will dramatically improve the health status of the current meat-only formulations. Salt and fat levels must be addressed, and the new formulations must be made available to the mass market and not just the elite consumer.

Another impressive feature of their approach is that they present solid evidence for the efficacy of not only the components included in their formulation but also the complete product. What I mean is this. They test the combined results of the remedy.

With these preliminary thoughts then, let’s delve into the matter at hand.

Their Methods and Subject Matter

My first job after three years of military service was in the industrial chemical environment. Here, Mervyn Niland, the inventor of Flight Hand cleaner taught me the five great rules of sales namely Attention, Interest, Desire, Objection and Close. The manufacturers of CircO2 do a brilliant job of getting one’s attention by introducing us to Mike (70), Eddie (60) and Des who looks closer to my age than Mike or Eddie. All living the kind of active life we all dream of. This was not always the case. Each person struggled with general health until they started giving attention to the one organ in the body often ignored. The “attention” they gave it was taking CircO₂.

From Attention to Interest

The marketing team of CircO₂ introduce the subject matter and immediately grab your attention which very quickly changes to interest.

1. They introduce us to the endothelium (a fun fact that I point out to Shannon Hounsell is that “if you could spread this organ out, the cells would cover almost 2 entire football fields!”) :-). The importance of endothelium in the health of all people and older people in particular is correctly highlighted. Related to Mike, Eddie and Des, “they all improved their health by improving the function of their endothelium” using CircO₂.
2. They then introduce us to a surprising discovery by an MIT scientist (look how credibility is introduced early in their presentation).

The attention and interest turn to desire when they list the benefits that Mike, Eddie and Des experienced namely:

✓Restored, healthy blood pressure…

✓ Supercharged energy!

✓ Waking up feeling well-rested and raring to go!

✓ Eliminating swelling in their joints…

✓ Improved memory…

✓ Restored flexibility to arteries…

✓ Improved lung function and reverse breathing difficulties…

✓ Plan a second honeymoon!

They achieved all this by improving the health of their endothelium!

Interest turns into Desire as the story of Nitric Oxide starts to unfold!

I share the link with all my friends from the high school class of ’87! The interest changes in desire! I want this!

After the surge of enthusiasm, some doubt creeps in. Am I being taken for a ride? As soon as it all sounds “too good to be true”, the MIT scientist appears back on stage with the story of his surprising discovery. The work of Robert Furchgott, a pharmacologist from New York and his groundbreaking discoveries from 1980, is introduced. It was Furchgott who discovered that “the endothelium controls your blood vessels which makes them relax and dilate when you need more blood flow. So, when the endothelium doesn’t work well, your blood flow is restricted.”

For the rest of this article, I will present my verbatim quotes from their literature with my comments in italics.

“While Furchgott was doing his research, 2 other scientists were doing research of their own. They discovered a mysterious molecule that seemed to appear out of nowhere and quickly spread throughout the body. Wherever it went, the molecule sent signals that affected the nearby cells.”

“When Furchgott found out about their research, he wondered if there was a connection with the endothelial cells. Turns out he was right! And when the 3 scientists combined their research, Furchgott’s mystery was solved! It turns out the signalling molecule was a very fragile gas called nitric oxide. Nitric oxide sends messages to the endothelium that tell it to relax and allow more blood flow. The nitric oxide discovery was so revolutionary that in 1998, it earned all 3 scientists the Nobel Prize. And it set off a massive wave of research around the world.”

Nitric oxide is essential for your health and overall well-being. It’s as important for your body as oil is for your car.

As you may know, if you stop getting the oil changed in a car, the engine will get gummed up. Eventually, it will run out of oil. And without oil, it won’t be long before your car suffers a critical engine failure.

Well, it’s the same with nitric oxide. But instead of it being an oil, it’s a gas that keeps the endothelium healthy, so your body stays fueled with oxygen and nutrient-rich blood.

And here’s something else you need to know about nitric oxide. It’s actually very fragile. It lasts only a few seconds before it disappears. So your body needs a constant new supply to keep you healthy and active. That’s why if a person is low on nitric oxide and suddenly gets more of it, they can feel the difference almost immediately.

Nitric oxide is nothing short of a health miracle maker! It’s so important that your body has 2 ways to make it.

The first way happens right in the endothelium. There’s a process that converts an amino acid called L-arginine [L-AR-jeh-neen] into nitric oxide.

But if your endothelium starts to get sluggish, the L-arginine has a harder time converting into nitric oxide. In fact, once people get past their 20s, their nitric oxide often plummets.

A study showed that most people in their 70s have lost 75% of their nitric oxide! No wonder so many people develop health symptoms and stop enjoying life.”

Why L-Arginine Supplements Usually Don’t Work

“Since the endothelium uses L-arginine to make nitric oxide, many people believe the problem is they don’t have enough L-arginine. So they think taking an L-arginine supplement will help. And you can find plenty of them on the market that promise to boost nitric oxide. But they’re usually a waste of money. Here’s why.

Studies show once the L-arginine is swallowed, your body immediately starts to break it down. By the time it’s ready to be absorbed into the bloodstream, it’s lost as much as 75% of its effectiveness.

What’s more, L-arginine isn’t well tolerated by some people. People who take it often suffer with bloating, diarrhea, nausea, and stomach pain. So researchers who study L-arginine now say people should avoid it. They don’t see any benefit in taking it and it could cause some unpleasant side effects.

Besides, you don’t need L-arginine to make nitric oxide! Because your body has a backup plan that gives you a steady stream of it.”

Your Body’s Backup Plan

“When your body has a harder time converting L-arginine to nitric oxide, it relies more on another way to make it. This one involves your diet.

You see, there are some foods that contain a certain nutrient. Your body uses the nutrient to make nitric oxide. And what’s so surprising is that it’s a nutrient people used to think was bad. That nutrient is nitrate.

That’s right… nitrate.

You may remember hearing that hotdogs are bad for you because they contain nitrates. And it’s true that eating hotdogs may be bad for you … but it’s not because of nitrates. It turns out nitrates are a vital nutrient because your body needs them to make nitric oxide.

So what healthier foods contain nitrates? Some of the best sources are beets, garlic, spinach, nuts and seeds, and dark chocolate.

Now you may already be eating some of these foods … maybe even a lot of them. Even so, you may still be low on nitric oxide.

Why? Because you need to eat a specific amount of nitrates to get the nitric oxide effect your body needs. That amount is 300mg.

We wish we could tell you exactly how many cups that would be of each of those nitrate-rich foods. But it’s difficult to know. Because the amount of nitrates in food varies dramatically depending on where and how plants are grown, how they were stored, and how they’re prepared.

For example, the nitrate level of a beet grown in one type of soil can have 50 times more nitrate than a beet grown in another type of soil!

But there’s another, even more surprising problem.”

Up to this point, the presentation is flawless. In the curing industry, we know nitric oxide as the curing molecule with broad-spectrum anti-bacterial and anti-viral properties. It is responsible for the cooked-cured colour of meat and much of the antimicrobial efficacy associated with the curing process. For many years the curing industry relied on the use of nitrate and nitrite to generate nitric oxide and it has only recently been discovered that nitric oxide is also generated through bacteria from L-Arganine. The sources for nitric oxide are therefore the same for the body as they are for the curing industry.

A well-known Spanish company produce a mixture of fruits and herbs which they propose to cure meat without nitrate and nitrite being present in them and also apart from L-Arginine. Company’s across Europe, England and Australia have bought into these claims and produce bacon and hams from them, notably one large company in the UK that proclaim that they sell bacon that was produced without any nitrate or nitrate and also without the use of bacterial fermentation from L-Arginine.

The Spanish company in effect claims to have discovered a source of nitric oxide besides nitrate, nitrate and L-Arganine. In a recent discussion with a Dutch friend about these claims, I pointed out that people are awarded the Nobel prize for the kind of discoveries alleged by the Spanish producer. There are others who also make similar claims. These companies in question operates in an environment of secrecy with clearly things to hide. It is fair to say they did not discover another source of nitric oxide! In contrast to them, the messaging by the producers of CircO₂ is refreshing, transparent and spot-on!

When they say that nitrate is a source of nitric oxide, what they also say by implication is that nitrite is an intermediary in the process, but I understand why they do not delve into this as it will distract them from their simple brand message. It is important for consumers to remember that and look into this.

The Common Habit That Robs You of Nitric Oxide

“Here’s that discovery we wanted to tell you about …

A scientist from MIT was researching how the body makes nitric oxide. And he found out something quite surprising.

It turns out that your body needs a special type of bacteria to start converting the nitrate in food into nitric oxide. And the bacteria live on your tongue. So the process needs to start in your mouth.

Without those bacteria, you could be eating nitrate-rich foods by the truckload, and you’d never make the nitric oxide your body needs to stay healthy. And get this …

It turns out 2 out of 3 people don’t have enough of the special bacteria! And it may surprise you to hear why.

If you take good care of your teeth, there’s a good chance you don’t have much of the special bacteria left.

That’s right. Most mouthwashes … and even fluoride toothpastes … kill the bacteria your body needs to make nitric oxide.

That’s why a person can eat a healthy diet, exercise, and still not stop the decline in nitric oxide as they age.

Luckily, you don’t have to sacrifice healthy teeth and fresh breath to boost your nitric oxide. Because the tongue bacteria discovery gave some scientists an idea.”

“The scientists were doing research at the University of Texas Health Science Center. And they discovered there’s a simple way to get your body to produce more nitric oxide. It works even if you have a sluggish endothelium.

They discovered that with the right ingredients, your body can still produce nitric oxide… provided the ingredients mix with a certain amount of the tongue bacteria. And after a lot of trial and error, the scientists discovered the winning formula. It’s a 5-ingredient combo that works like magic!

The scientists had another problem to solve. They had to figure out how to get the ingredients to mix with enough of the bacteria. That meant a pill or a drink wouldn’t work because they don’t spend time in your mouth.

So to solve the problem, they created a special lozenge. As it dissolves in your mouth, it mixes with just enough of the bacteria to get the nitric oxide process started. And the results are amazing!”

The ingredients they discuss are of interest and have been and are currently the subject of active study by me and a colleague, Richard Bosman. So, it is of great interest to continue looking at their ingredients within the context of nitrate, nitrite and nitric oxide but before we do so we must look again at the method they chose for taking their product which is actually nothing novel.

They re-discovered what has been known since antiquity. The oldest prescription that describes a similar action is the Dunhuang manuscript discovered in the Mogao Caves in the far Western region of China by a Daoist monk, Wang Yuanlu on 25 June 1900. The mix of religious and secular documents dates from the 5th to the early 11th centuries. One text is of particular interest to us, referred to as the Dunhuang Medical Text. The text is attributed to the famous Daoist alchemist and physician Toa Hongjing (CE 456 – 536).”  (Cullen, C, Lo, V.;  2005) There is evidence that it relies on earlier traditions from the Han and Sui Dynasties.  “The original was decorated with images of the Three Daoist Lords and the Twelve Constellations, indicating links with Doist traditions.  In translation, it reads as follows: 

“The symptoms described by the patient, as described in the Dunhuang manuscript, suggests an advanced case of cardiovascular distress. The colour of the fingernails (cyanosis) indicates ischaemia (lack of oxygen in the tissue) due to restricted blood flow. Cold hands and feet are additional symptoms of this condition. Also, acute pain suggests that the patient may be suffering from severe angina, i.e. restricted blood flow due to the narrowing of the cardiac arteries.”  (Cullen, C, Lo, V.;  2005)

“Modern treatment for angina is glyceryl trinitrate or isosorbide dinitrate. So, at first glance, there seems to be a similarity in treatment.  All three remedies contain the all-important nitrate. Salpeter is, however, an inorganic compound that exists as a positively charged potassium cation (K+) and a negatively charged nitrate anion (NO3-). Concerning organic nitrate, such as glyceryl trinitrate, there is a covalent bond or a molecular bond between the nitrate moieties (NO3) where they share electron pairs which form the bond with the rest of the molecule (CH2). Where glyceryl trinitrate relaxes the muscle lining of the artery to relax, enlarging the vessel and so allowing more blood flow, saltpetre by itself will have no effect on the treatment of angina.(Cullen, C, Lo, V.;  2005)

This is, however, not the full story. The remarkable feature of the Dunhuang text is that the combination of the use of saltpetre (which is nitrate), not on its own, but when applied according to the dictates of the text, becomes a remedy for exactly the condition described. “The thing about glyceryl trinitrate is that this too, in itself, is not a vasodilator (relaxing of the arterial lining).  It is transformed, probably in the arterial wall, into nitric oxide, a chemical species which is the vasodilator. Under very special circumstances, exactly as detailed in the Dunhuang text, <beginning with microbial conversion of nitrate to nitrite by bacteria in the tongue,> the nitrate ion from saltpetre also converts to exactly the same species which is the vasodilator (nitric oxide). Despite the fact that glyceryl trinitrate has been in use for over a hundred years, the identity of this species has only been discovered in 1987.”  (Cullen, C, Lo, V.;  2005) The discovery is what the producers of CircO2 have been describing and the reason for the efficacy of the Dunhuang text related to saltpetre is exactly the reason why CircO2, replete with beetroot, a rich source of nitrate is effective to produce nitric oxide in the body and their method of changing nitrate into the species which can achieve the production of nitric oxide is what is done with nitrate in CircO2.

The efficacy of these methods of taking the compounds describes rests on the reduction of nitrate to nitrite in the mouth. As I stated before, the owners of CircO₂ do not discuss this, but for the meat curing industry, it is important to note that this reaction is the key issue here. The conversion of nitrate to nitrite by bacteria that was known since antiquity (even though they could not have understood the exact mechanism) turns out to be a very important feature of human existence and health, generally.

Bryan (2011) points to this key relationship between nitrate and nitrite with nitric oxide when he writes that “from research performed over the past decade, it is now apparent that nitrate and nitrite are physiologically recycled in blood and tissues to form Nitric Oxide and other bioactive nitrogen oxides.” One of the important sources of nitrite is “Nitrite is also derived from the reduction of salivary nitrate by bacteria in the mouth and in our stomachs. This is the basis for the efficacy of both Circo₂ as well as the remedy prescribed in the Dunhuang manuscript. Bryan expands on this, that another source of nitrite is “from dietary sources such as meat, vegetables and drinking water.” The meat he refers to is probably fresh meat, but we know cured meat is an extremely good source of dietary nitrite. In order for nitrate to become effective in our metabolism, it must first be changed into nitrite, and because mammals lack specific and effective enzymes to do this conversion it is mainly carried out by bacteria in the mouth and stomach or by bacteria that are found on our skin. I deal with this in detail in a chapter in my book on meat curing. The chapter is called The Curing Molecule.

“Once in the mouth, . . . bacteria change nitrate to nitrite. This change requires the presence of these bacteria — suggesting a functional symbiosis relationship — as mammalian cells cannot effectively metabolize nitrate. “When saliva enters the acidic stomach (1 — 1.5 l/day), much of the nitrite is rapidly converted to nitrous acid, which decomposes further to form Nitric Oxide and other nitrogen oxides. This human nitrogen cycle is illustrated below. Once nitrite is absorbed and circulated, it is taken up by peripheral tissues and can be stored in cells.” Bryan (2011)

The image above if from Bryan (2011).

Now back to the ingredients in CircO2.

The Weed That Keeps Your Blood Flowing Like Niagara Falls!

The first ingredient they mention is hawthorn. “It’s been used in Asia since the 1st century to help people with heart, circulatory, and respiratory troubles. And modern scientific research confirms that hawthorn has a remarkable ability to protect endothelial cells from damage.

As you saw earlier, when your endothelium is damaged, your blood flow is restricted. This starves your cells of fresh oxygen and nutrients … including your endothelial cells. This shortens their life and starts a vicious cycle.

As your endothelial cells die, your blood flow becomes more restricted, which causes more endothelial cells to die. And around it goes.

Hawthorn breaks the vicious cycle … and throws it into reverse! It does it by protecting the endothelial cells from damage.

In fact, researchers tested hawthorn extract against several other powerful medicinal herbs. And hawthorn gave endothelial cells 6 times more protection from damage! That means they live longer. That helps repair your endothelium, which improves your blood flow and brings your starving cells back to life.”

The next two ingredients are beetroot and L-Citrulline.

The 2 Most Powerful Nitric Oxide Boosters

“The first one is beet root powder. Beet root powder is loaded with health benefits! It’s a powerful antioxidant … it fights inflammation … it improves brain function … and it’s an amazing source of nitrates. That makes it a nitric oxide-producing powerhouse! In fact, a study showed drinking beet root juice almost doubles your nitric oxide!

In the study, researchers timed a group of people riding a stationary bike until they were too exhausted to continue. They also measured their nitric oxide levels, how much oxygen the participants had in their blood, and how much got into their muscles. Then they split them into 2 groups.

One group got beet root juice to drink every day for 6 days. The other group got a sham drink that tasted like beet root juice but didn’t have any nitrates in it.

At the end of the study, the people came back and were tested again. And the researchers were astonished by what they saw!

The people drinking beetroot juice increased their nitric oxide by 96%! That’s almost double! But not only that…

Instead of gasping for air, they needed less oxygen to pedal … and they could pedal longer, too. But the people who got the fake drink didn’t see any benefit whatsoever.

Beetroot is one of the best nitric oxide-boosters you can find.”

Beetroot juice is replete with both nitrate and nitrite. The fact that the tablet is held in your mouth means that nitrate-reducing bacteria change nitrate into nitrite so that even more nitrite is swallowed. It completely obliterates the tight link that popular science presented for years that nitrite = cancer. The fact that CircO2 not only include it in their remedy but even prescribe the action of holding it in your mouth for a while before swallowing it is a stunning reversal of the old and outdated view of nitrites.

Their formula “also contains an ingredient that gets around the L-arginine problem. And it helps your endothelium make more nitric oxide, too.”

Helps Your Endothelium Make More!

As we mentioned earlier, taking L-arginine supplements doesn’t do much to help your body make nitric oxide. And besides, there’s something even better you can do.

You can get your body to make more L-arginine! How? With something called L-citrulline [L-sit-true-lean].

L-citrulline is an amino acid that your body uses to make L-arginine. And your digestive system doesn’t break L-citrulline down. L-citrulline gives you other benefits, too.

It improves concentration, increases blood flow, and reduces muscle fatigue. In fact, a study found L-citrulline can even give you more muscle power.

In this study, the researchers split people into two groups. One group took L-citrulline capsules for 7 days. The other group took capsules filled with a cornstarch placebo. After a week, both groups met with the researchers for testing.

First, the researchers tested their level of L-arginine. And they were amazed! In just 7 days, the people taking the L-citrulline had an astonishing 38% more L-arginine in their bodies!

Then both groups were tested to see how fast they could ride 4-kilometers on a stationary bike. The L-citrulline group finished faster! But the researchers had to make sure it was because of the L-citrulline. So they did the study a second time. Only they switched the capsules. So the ones who got the L-citrulline the first time got the placebo, and vice versa.

And the results from the second test confirmed it! In each case, the L-citrulline group had more L-arginine and finished the bike race faster. Not only that … the people all said when they took the L-citrulline, their muscles didn’t feel as tired. And they noticed they had more concentration.

So L-citrulline helps your body both physically and mentally. And it keeps your level of L-arginine elevated so your endothelium can make nitric oxide all day, without any side effects.

The 2 Essential Nitric Oxide Vitamins

Their remedy also contains 2 vitamins that are essential to your body’s ability to make and use nitric oxide.

Vitamin B12: Many people don’t get enough B12, or they have trouble absorbing it. B12 is important because it protects the nerve endings in your brain. People who don’t get enough of it often notice they have problems with their memory.

Not only that. Low B12 is shown to lower your nitric oxide levels too. That’s why CircO₂ has 1000 mcg of B12. This helps your body to make nitric oxide, while also giving your memory a boost!

Vitamin C: You already know that vitamin C is great for supporting your immune system. Well studies show it also helps your body make nitric oxide … especially when you’re over 60.

Right around the age of 60, people’s bodies start having a hard time clearing out toxins. And toxic build-up is one of the things that wears out your endothelium. But vitamin C is shown to seek out and remove the toxins that weaken your endothelium.

The combination of these 5 powerful nitric oxide-boosting ingredients … in a delicious lozenge that melts on your tongue … makes CircO₂ the best nitric oxide-booster you can find. And the results speak for themselves.

In cured meats, adding vitamin C fulfils another important function besides its value in CircO₂. It is legislated in most countries on earth, that wherever nitrites are used to cure meat, vitamin C must be part of the formulation because it blocks the possible formation of nitrosamines in the human body. The link with cancer is the formation of nitrosamines the possible formation which is prevented by adding vitamin C. (Mirvish, 1975) This, the fact that vitamin C is added to all cured meats, together with the minuscule amounts of nitrites used in meat curing, considered in the comparatively massive amounts that it exists in leafy green vegetables such as beetroot and spinach, it key physiological function in the human body, the amounts swallowed every day from our saliva, all points to nitrite in cured can not possibly be the reason why some studies point to possible health concers associated with it.

The fact that a product like CircO2 exists is a testimony to the erroneous science that concluded that nitrite is to blame for any possible adverse health effects of cured meat. I appreciate how the owners of the CircO2 referred to it that hotdogs may be unhealthy, but it is not for the inclusion of nitrates (and by implication, nitrites). What is interesting is that the possible reasons why certain brands of cured meat are unhealthy are far more within the control of the processor than the use of nitrite and ultimately nitric oxide without which meat can not be cured.

Boosts Nitric Oxide in Just 20 minutes!

The point of quoting their presentation is to show that when one talks about nitrite, nitrate and nitric oxide and you ingest it through cured meat, leafy green vegetables or the formulation, CircO₂, the results are almost instantaneous!

Most supplement companies rely on studies that test the individual ingredients in their supplements. But they never study how people respond to the product itself. That’s not the case with CircO₂. In fact there are several studies that show how well the actual CircO₂ lozenge works.

In one study, researchers gave people the lozenge to dissolve on their tongue. Then every 5 minutes, the researchers used the same process we mentioned earlier to measure the amount of nitric oxide in their body. They kept measuring them for over an hour. And the results were astonishing!

The participants’ nitric oxide levels began to rise almost immediately. In less than 20 minutes, their nitric oxide was 650% higher! And it stayed elevated, too!

In another study, researchers tested the formula on a group of people aged 42 to 79. All of them had high triglycerides.

The researchers split them into two groups. One group got a box of lozenges with the CircO2 ingredients, and the other got a placebo. They were told to let a lozenge dissolve on their tongue every morning and evening.

When the 2 groups returned 30 days later, the researchers tested their triglycerides again. The CircO₂ group’s triglycerides dropped by as much as 55% … without making any other changes to their lifestyle!

But even better was how the CircO2 group felt. At the end of the study, the participants from both groups filled out a questionnaire. Many people in the CircO2 group said they:

– Felt more relaxed

– Slept better

– Had more energy

– Were less anxious

And most of them said they felt so good they wanted to continue taking the lozenge.

There’s just no denying it! You feel noticeably better when your cells are flushed with oxygen and nutrients! And it makes you healthier, too.

Nitric oxide can do more for your health and well-being than practically anything else I’ve seen. In fact, I’m shocked that the standard screening tests we get when we’re older don’t include a way to test for nitric oxide.

Having masterfully taken us through the steps of attracting our attention, piquing our interest, motivating a desire for their product to develop, and overcoming objections, they now close the deal with links to their order portal and the promise of a healthy and bright physical future.

Conclusion

For those interested to learn more about CircO2, either do an internet search or visit advancedbionutritionals. Products like these will continue to become available based on the latest research. The wellness and sports nutrition industry are far advanced in embracing the value of nitrite, nitrate and nitric oxide.

The curing industry is lagging behind in assimilating this research into its own messaging and in formulating new and improved products that embrace similar research that not only show that nitrite does not equate to cancer, and instead embraces the full spectrum of the benefits of plant components.

This is the sole focus of the work of Richar Bosmann and me. It should be a major focus for everyone!

A South African friend living in Australia sent me a message this morning about an evaluation I did about the recently launched no-nitrite bacon from Woolworths which I suspect to be similar to the Spanish company I described earlier (Evaluation of Woolworths “contain no nitrites” Bacon). He wrote, “I have read this morning an interesting article from Prof Henry Mintzberg where he was writing about Milton Friedman’s doctrines and Henry said the following: ‘When the corporation knows more than its clients do, there is room for deception. A good deal of advertising can be described as manipulative in nature, that is, designed not to inform but to affect ― to create emotional need or dependency. To the extent that this kind of advertising works ― expressly as it is designed to ― then to use Friedman’s terms, it coerces the consumer and evokes involuntary cooperation, thereby distorting consumer sovereignty.” This is exactly NOT the kind of advertising that CircO₂ practices and as excited as I am by them bringing the subject matter they address into the popular mass media, I think their approach is a rebuke to a lack-lustre response by the meat industry! They certainly seek to educate with integrity and capitalise where the meat industry seems to do nothing!

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References

Bryan NS. Application of nitric oxide in drug discovery and development. Expert Opin Drug Discov. 2011 Nov;6(11):1139-54. doi: 10.1517/17460441.2011.613933. Epub 2011 Aug 25. PMID: 22646983.

Cullen, C, Lo, V..  2005.  Medieval Chinese Medicine: The Dunhuang Medical Manuscripts.  Routledge Curzon.

Mirvish SS. Blocking the formation of N-nitroso compounds with ascorbic acid in vitro and in vivo. Ann N Y Acad Sci. 1975 Sep 30;258:175-80. doi: 10.1111/j.1749-6632.1975.tb29277.x. PMID: 1106296.

Full text from CircO₂ literature was from Advancedbionutritionals.